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What is Ketamine?
Ketamine (brand name Ketalar) is a dissociative anesthetic (blocks sensory perception) that has been available by prescription in the U.S. ketamine drug, since the 1970s for human and veterinary uses. Dissociative drugs can lead to distortion of sights, colors, sounds, self, and one’s environment. ketamine clinic, It is available in a clear liquid or off-white powder form for intravenous injection. ketamine depression treatment, Other dissociative drugs include phencyclidine (PCP) and dextromethorphan (DXM)
- Ketamine can provide pain relief and short-term memory loss (for example, amnesia of a medical procedure).
- In surgery, it is used an induction and maintenance agent for sedation and to provide general anesthesia.
- It has also been used for pain control in burn therapy, ketamine side effects, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
- This drug is also under research and holding promise as a treatment for severe depression in difficult cases.
- It is often preferred as an anesthetic due to a lower chance for depressed breathing, as often occurs with opioids.
Pharmacology of Ketamine
Pharmacologically, ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, but at higher doses may also bind to the opioid mu and sigma receptors. ketamine definition, This drug disrupts the neurotransmitter (brain chemical) glutamate. Glutamate is involved with learning, memory, emotion, pain recognition. ketamine clinic, It can exhibit sympathomimetic activity which can lead to rapid heart rate and elevated blood pressure.
It is related to phencyclidine (PCP), but has less than 10% of the potency of pure PCP.
This agent is a lipid soluble compound, has an initial rapid distribution and large volume of distribution, with a half-life of 10 to 15 minutes. ketamine and depression, ketamine for pain, Secondarily, ketamine treatment, the drug distributes into peripheral tissues with a slower elimination half-life of up to 3 hours, undergoes hepatic metabolism and is excreted in the urine
How Quickly Does Ketamine Work?
- An injection yields a quick response, with effects occurring in 1 to 5 minutes.
- “Snorting” takes roughly 5 to 15 minutes.
- Oral consumption requires between 5 and 30 minutes.
The effects of abuse typically last 1 to 2 hours, but the users judgement, senses and coordination may be affected for up to 24 hours or longer. ketamine high, ketamine treatment, Sensations the user may seek include floating, stimulation and visual effects.
High doses may dangerously reduce breathing, lead to muscles spasms or weakness, ketamine clinic, dizziness, balance difficulty, impaired vision, slurred speech, nausea and vomiting, ketamine treatment, and severe confusion.
Binge use, where the user indulges in the drug in excess amounts in a short period of time has been reported, as well.
Ketamine Recreational Dose Ranges
|75 to 125 mg||Intramuscular (IM) injection|
|60 to 250 mg||Insufflation (intranasal or “snorting”)|
|50 to 100 mg||Intravenously (IV)|
|200 to 300 mg||Orally (by mouth)|